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Bacillus clausii UBBC-07®

Clinically researched, well-characterized & highly-stable Bacillus clausii probiotic for your application
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Years of experience
Clinical Studies
Global Certifications

Benefits of Bacillus clausii UBBC-07® for Manufacturing Companies

Can withstand environment of stomach acid & bile juice to reach intestine where it colonizes. Survives food processing conditions.
No Microencapsulation
Needs no microencapsulation which makes it a cost effective probiotic
Can survive shipping, manufacturing & transport processes without loss of viability.
Non pathogenic, full identity characterization by phenotypic & genotypic means.
Stable at room temperature, requires no refrigeration.
Temperature Resistant
Can survive greater range of temperatures (zone IV b)
Bacillus clausii Bacteria's

Bacillus clausii UBBC-07® is a well-documented and thoroughly characterized strain that has been widely used to help in the treatment of diarrhea. Bacillus clausii UBBC-07®, belonging to genus Bacillus, has been demonstrated to benefit the intestinal environment by modulating gut microbiota, improving immune response, and reducing intestinal pathogen colonization. In addition, it has been found to improve the immune response by stimulating the production of cytokines such as TNF-alpha and INF-gamma in the mice model system.

Bacillus clausii UBBC-07® contains lyophilized bacillus clausii spores, recognized for their beneficial effects on intestinal health. It exists in a spore form to resist gastric acidity and bile and thus reach the intestines in an active state. The spores germinate into vegetative cells that colonise the gastrointestinal tract, where they become a part of the normal gut microflora and confer their beneficial effects. The advantage of B.clausii UBBC-07® is that it is resistant to a wide range of antibiotics and can be administered concomitantly.

Lactobacillus Bacillus clausii is commonly found in nature, such as soil, water, and dairy products. Multiple studies prove B.clausii to be a safe probiotic with no serious adverse effects reported from human trials even with long-term use, making it one of the most trusted strains for Bacillus clausii supplements production. Once ingested, Bacillus clausii UBBC-07® germinates into active vegetative cells that colonise the GI tract for at least seven days. The mechanism of action is twofold:
Competitive exclusion (CE): UBBC-07® produces copious amounts of bacteriocins that inhibit the growth and attachment of enteropathogenic bacteria like Salmonella typhi and Clostridium difficile.
Enhanced immune response: The production of heat shock protein 70 (HSP70) stimulates the innate immune response by activating macrophages, T lymphocytes, and dendritic cells.


Our Certifications

Critical Properties of Bacillus clausii UBBC-07

  • Safe to use in the production of food products.
  • Rapid growth rate producing high cell yields.
  • High bacitracin titers (up to 2 g/l) with good product quality.
  • Producers are suitable for fermentation under aerobic and anaerobic conditions with pH control.
  • It can be used as probiotics in dairy products because it is GRAS and can survive in simulated gut conditions.
  • It can be consumed in the form of drugs (bacillus clausii capsules, tablets, or powder form), food supplements, or added as an ingredient in different foods and beverages.

Features of Bacillus clausii UBBC-07®

Compatible with all product forms- liquids, solids, dry powders, semi-solids. Can be easily mixed to any.
Can be incorporated in various applications. Does not alter the sensory properties of the product.
Food & beverage packed with multiple health benefits. Taking it in any form would help improving overall fitness.
Resilient to harsh manufacturing conditions like temperature variations, shear, pasteurization, etc.
Resistant to antibiotics and has ability to form spores that maintain viability over long periods
Bacillus clausii Dosage

The standard dose of Bacillus clausii spores suspension is 1-2 tablespoons (5 ml or 10 ml), twice daily. The product must be taken on an empty stomach, at least one to two hours before a meal. The suspension can be taken directly from the bottle, or it can be dissolved in water.
The exact dose of Bacillus clausii spores suspension depends on the patient's age and their specific medical needs. Bacillus clausii UBBC - 07® is a beneficial probiotic strain of Bacillus clausii that Unique Biotech (India) Limited has developed after years of research. This particular strain is capable of producing high amounts of Lactic Acid.
This property makes it particularly important for the Food & Beverage industries, where it can be used to manufacture various edible products. For example, this product can be used to produce dairy products and other products such as Yoghurt, Buttermilk, Gummies, Protein bars, Chocolates, Breakfast cereals, Flavoured Water, etc.

Various fortification opportunities

Food and Beverage companies can use Unique Biotech probiotics as an ingredient for various food and beverages like...

  • Gummies
  • Protein bars
  • Chips
  • Chocolates
  • Breakfast cereals
  • Flavoured Water
  • Fruit Juices
  • Tea
  • Shakes
  • Kombucha

Stability of UBBC-07® in food & beverages

Food Products
Dark Coffee
Light Coffee
FOS & Insulin in water
Thumbs Up
Mineral water
Herbal Extract
Sports drink
Soya Sauce
85% Sugar Syrup
%age Stability
90% & 100%
87.6 %
100 %
100 %
85 %
4hrs at 90 deg celsius
2min at 90 deg celsius
14 months
8 months
8 months
8 months
12 months
12 months
6 months
12 months
12 months
24 months
12 months
1 month
4hrs at 90 deg celsius

Our Services

Contract Manufacturing

We have a WHO-GMP certified, state of the art facility dedicated to the manufacturing of probiotics, In house quality assurance laboratory and innovative packaging solutions.

Private Label

Offer probiotic blends under your brand name. The finest quality & improved efficacy of our products will allow you to successfully differentiate yourself amongst competitors

Customized Blends

We offer ready-to-fill blends in bulk for your customized blends.

Analytical Support

Our regulatory and marketing teams provide documentation that makes it extremely easy for our partners to register our products in their respective regions.